Kane Lab

Immunity to Retroviral Infections 

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Investigating host-retroviral interactions

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HIV-1, Mx2, and the nuclear pore complex

How does nuclear pore heterogeneity affect the antiviral activity of Mx2?

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Genetic basis for retrovirus resistance

What are the genes responsible for protective antiviral responses in retrovirus resistant individuals?

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Intrinsic cellular defenses

How do intrinsic innate immune effectors restrict retroviral replication?

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Antiretroviral immune responses

What are the signaling pathways underlying neutralizing antiretroviral immune responses in resistant individuals?

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Where we are

Children’s Hospital of Pittsburgh

Center for Microbial Pathogenesis

University of Pittsburgh School of Medicine